An impact of activated Epstein–Barr Virus and HHV-6 on the course and control of bronchial asthma in children of the Amur Region

The role of viral infection in bronchial asthma (BA) is well-known being reflected particularly GINA. An effect pneumotropic intracellular persistent herpesviruses on the course BA particular interest. most common viruses this group are cytomegalovirus (CMV), EpsteinBarr virus (EBV), and human herpesvirus 6 (HHV-6). CMV has been discussed our previous publications allowing us to focus here EBV HHV-6. We examined 167 children with that was diagnosed clinically assessed accordance current national clinical guidelines. Patients controlled (70 patients), partially uncontrolled (97 patients) were stratified into several groups. detection HHV-6 DNA carried out throat swabs by PCR; level total virus-specific IgA, IgM, IgG, IgE as well serum IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-8 TNF enzyme linked immunosorbent assay; lymphocyte subpopulations analyzed flow cytometry. dose topic GCS taken account reference fluticosone equivalent; function external respiration studied spirometry. It revealed found 14.2% cases, whereas 19.0% but 14.4% 52.4% patients, respectively, shed no pathogen-linked DNA. At same time, patients significantly more likely pathogen DNA, so released 17.1% vs 4.5% BA, 19.5% 13.6%. On contrary, often (63.6% 51.2%) negative for shedding. Moreover, shedding paralleled higher levels IL-5: it high 0.91 pg/ml 0.29 HHV-6, respectively; those both pathogens had IL-5 at 0.25 0.11 pg/ml. Similar pattern observed IgE: 184.5 IU EBV, 113.1 371.7 95.2 without shedding; lower FEV1: 96.6%, 98.8%, 106.2% 109.8% not require doses achieve disease control: 325.0 mg, 186.4 mg; 328.1 mg 198.6 Thus, activation worsens control aggravates its course, persistence a pronounced disease.